Use of All-Trans Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia
نویسنده
چکیده
Twenty-four patients with acute promyelocytic leukemia (API) were treated with all-trans retinoic acid (45 to 100 mg/m2/day). Of these. eight cases had been either nonresponsive or resistant to previous chemotherapy; the other 1 6 cases were previously untreated. All patients attained complete remission without developing bone marrow hypoplasia. Bone marrow suspension cultures were studied in 1 5 of the 24 patients. Fourteen of these patients had morphological maturation in response to the retinoic acid (1 ,tmol/L). Chloroacetate esterase and a-naphthyl acetate esterase staining as well as electronmicroscopic examination confirmed that retinoic acid-induced cells differentiated to granulocytes with increased functional maturation (as measured by nitroblue tetrazolium reduction. NBT). The single nonresponder to retinoic acid in vitro was
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